Dimitris Karamichos, PhD

  • Assistant Professor, Department of Ophthalmology
  • Assistant Professor, Department of Cell Biology
  • Member/Faculty, Oklahoma Center for Neuroscience
  • Dimitrios-Karamichos@ouhsc.edu
    • Special Interests

      • Corneal wound healing and the mechanisms of fibrosis and regeneration
      • The role of the transforming growth factor-3 (TGF-β3) in directing fibrosis in the cornea
      • Development of in vitro and in vivo models for the understanding of Keratoconus disease
      • The identification of new markers for the treatment of the Keratoconus disease

      Training

      • Postdoctoral Training, University College London, Institute of Orthopaedics, London, UK
      • Postdoctoral Training, UT Southwestern Medical Centre, Department of Ophthalmology, Dallas ,TX, USA
      • Senior Research Associate, Harvard Medical School, Schepens Eye Research Institute, Boston, MA, USA
      • Investigator, Harvard Medical School, Schepens Eye Research Institute, Boston, MA, USA
      • PhD in Tissue Engineering/Molecular Biology, University College London, London, UK
      • MSc in Engineering and Physical Sciences in Medicine, Imperial College, London, UK
      • BEng (Hons) in Electrical and Electronic, Manchester Metropolitan University, Manchester, UK

      Research Summary

      My research interests are focused on cornea wound healing and cornea dystrophies. Millions of people throughout the world lose their vision due to some kind of cornea injury/trauma. It is my career focus to investigate, research, and understand how specific processes work and develop new therapeutic techniques that can help humans partially or fully restore their vision. One area of interest is the effect of the transforming growth factor-β3 or TGF- β3 on corneal stromal cells and their extracellular environment. We have published several manuscripts that report TGF-b3 s effect on guiding stromal cells towards a non-fibrotic / non-scarring phenotype as well as secreting and assembling an extracellular matrix (ECM) that mimics corneal stroma in vivo. The second area of interest belongs to corneal dystrophies. Corneal dystrophies are rare conditions in which the cornea is altered without the presence of any inflammation, infection or other eye disease. The transparency of the cornea is affected and the individual may or may not see vision disturbance. We are interested on looking into a cornea dystrophy named Keratoconus. The name literally means "conical or cone-shaped cornea" and normally appears at puberty. In keratoconus the cornea becomes stretched and thins at its center. The thinned part of the cornea then bulges creating vision distortion. Keratoconus tends to progress but the rate varies. We have recently published the first in vitro model that may allow the studying of the Keratoconus cells in vitro as well as their signaling pathways and ECM assembly. We have extensive collaborations with multiple institutions, surgeons and academics for ongoing research involving humans with Keratoconus disease.

    Recent Publications

    Click http://www.ncbi.nlm.nih.gov/pubmed/?term=karamichos and http://connects.catalyst.harvard.edu/Profiles/display/Person/72013 for a list of this investigator's publications.

    Funding Sources

    http://www.nih.gov/
    http://www.nei.nih.gov/